Abnormal Mesenchymal Differentiation in the Superior Semicircular Canal of Brn4/Pou3f4 Knockout Mice
نویسندگان
چکیده
منابع مشابه
Abnormal mesenchymal differentiation in the superior semicircular canal of brn4/pou3f4 knockout mice.
OBJECTIVE To examine the developmental time course of the mutant phenotype and cellular mechanisms that result in malformations of the superior semicircular canal (SSCC) in Brn4 knockout mice. Mutations in the Brn4/Pou3f4 gene result in characteristic inner ear abnormalities in mutant mouse pedigrees, and the findings in these mice are similar to those in human X-linked deafness type III. DES...
متن کاملSuperior semicircular canal dehiscence syndrome
Key points • The Tullio phenomenon is sound-induced vertigo, nystagmus, or both. • Hennebert sign is pressure-induced vertigo, nystagmus, or both, elicited by insufflation of the external auditory canal. • Typically, in affected patients with superior semicircular canal dehiscence syndrome, there is a several-year history of symptoms that may include sound-induced vertigo (Tullio phenomenon), p...
متن کاملSuperior semicircular canal dehiscence syndrome
This article discusses superior semicircular canal dehiscence syndrome. This syndrome has been identified in 1998 by Minor etal. This condition is caused due to dehiscence of bone overlying the superior semicircular canal. This causes vertigo, oscillopsia, dysequilibrium due to exposure to sound. Ultra high resolution CT scans help in identification of this condition. This dehiscence has been c...
متن کاملTransmastoid repair of superior semicircular canal dehiscence.
OBJECTIVE The aim of this study was to describe the successful operative management of a patient with superior semicircular canal dehiscence syndrome, using the transmastoid approach under local anaesthesia. METHODS The transmastoid approach was used to plug the superior semicircular canal. RESULTS Post-operatively, the patient experienced significant improvement in his symptoms of sound- a...
متن کاملClinical manifestations of superior semicircular canal dehiscence.
OBJECTIVES/HYPOTHESES To determine the symptoms, signs, and findings on diagnostic tests in patients with clinical manifestations of superior canal dehiscence. To investigate hypotheses about the effects of superior canal dehiscence. To analyze the outcomes in patients who underwent surgical repair of the dehiscence. STUDY DESIGN Review and analysis of clinical data obtained as a part of the ...
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ژورنال
عنوان ژورنال: Archives of Otolaryngology–Head & Neck Surgery
سال: 2005
ISSN: 0886-4470
DOI: 10.1001/archotol.131.1.41